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CABI Book Chapter

A handbook of environmental toxicology: human disorders and ecotoxicology.

Book cover for A handbook of environmental toxicology: human disorders and ecotoxicology.

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Chapter 31 (Page no: 457)

UV exposure and skin-protective effects of plant polyphenols.

Skin exposure to ultraviolet (UV) radiation triggers a plethora of harmful effects, including skin cancer. UV radiation is linked to DNA damage, inflammation, oxidative stress, immunodepression, photoageing and extracellular matrix degradation. In this context, UV protection has emerged as a global concern not only for cosmetic purposes but also with clinical relevance. Industrial and scientific communities have tried to address this problem using different molecules for sunscreens that act as physical barriers. Despite these advances, major progress is still needed to find effective photoprotective formulations. Natural compounds, especially plant polyphenols, comprise an almost limitless source of bioactive compounds with a variety of beneficial effects. Polyphenols have shown the capacity to alleviate most of the harmful effects of UV radiation in skin cells models. However, in vivo evidence for such activity is still scarce. Further, knowledge of the metabolites responsible for this photoprotective activity is very limited. This chapter reviews the most relevant results on the use of selected polyphenols to reverse the consequences of UV radiation on skin, focusing on their main molecular targets and their putative molecular mechanism.

Other chapters from this book

Chapter: 1 (Page no: 3) Phytotoxins. Author(s): D'Mello, J. P. F.
Chapter: 2 (Page no: 19) Mycotoxins. Author(s): D'Mello, J. P. F.
Chapter: 3 (Page no: 33) Cyanobacterial toxins. Author(s): Metcalf, J. S. Souza, N. R.
Chapter: 4 (Page no: 49) Amino acids and peptides as mediators of abiotic stress tolerance in higher plants. Author(s): D'Mello, J. P. F.
Chapter: 5 (Page no: 75) Ozone I. Human disorders: an overview. Author(s): Silveyra, P. Fuentes, N. Rivera, L.
Chapter: 6 (Page no: 93) Ozone II. Biophysical observations. Author(s): Thompson, K. C.
Chapter: 7 (Page no: 105) Nitrogen dioxide: ambient exposure in human disorders. Author(s): Huang, Y. C. T. Tucker, J. L.
Chapter: 8 (Page no: 114) Sulfur dioxide and human disorders. Author(s): Ahmad, S. Ahmad, A. Ahmad, A.
Chapter: 9 (Page no: 127) Plant response to acid rain stress. Author(s): Liang, C.
Chapter: 10 (Page no: 141) Polycyclic aromatic hydrocarbons: ecotoxicity in the aquatic environment and implications for human health. Author(s): Pampanin, D. M. Schlenk, D.
Chapter: 11 (Page no: 156) The developmental neurotoxicity of polychlorinated biphenyls: a continuing environmental health concern. Author(s): Sethi, S. Lein, P. J.
Chapter: 12 (Page no: 173) Dioxins I. Dynamics and legal directives in Europe. Author(s): Dopico, M. Gómez, A.
Chapter: 13 (Page no: 187) Dioxins II. Human exposure and health risks. Author(s): Tuomisto, J. Viluksela, M.
Chapter: 14 (Page no: 206) Dioxins III. Relationship to pre-diabetes, diabetes and diabetic nephropathy. Author(s): Everett, C. J.
Chapter: 15 (Page no: 214) Environmental endocrine-disrupting chemicals and human health. Author(s): Darbre, P. D.
Chapter: 16 (Page no: 233) Organochlorine insecticides: neurotoxicity. Author(s): Caudle, W. M.
Chapter: 17 (Page no: 246) Organophosphates I. Human health effects and implications for the environment: an overview. Author(s): Wille, T. Thiermann, H. Worek, F.
Chapter: 18 (Page no: 261) Organophosphates II. Neurobehavioural problems following low-level exposure: methodological considerations for future research. Author(s): Ross, S. J. M. Harrison, V.
Chapter: 19 (Page no: 282) Glyphosate as a glycine analogue. Author(s): Seneff, S.
Chapter: 20 (Page no: 299) Crude oil pollution I. Deepwater Horizon contamination: human health effects and health risk assessments, a case study. Author(s): Wilson, M. J.
Chapter: 21 (Page no: 311) Crude oil pollution II. Effects of the Deepwater Horizon contamination on sediment toxicity in the Gulf of Mexico. Author(s): Montagna, P. A. Arismendez, S. S.
Chapter: 22 (Page no: 320) Crude oil pollution III. Exxon Valdez contamination: ecological recovery, a case study. Author(s): Haycox, S.
Chapter: 23 (Page no: 334) Review of studies of composition, toxicology and human health impacts of wastewater from unconventional oil and gas development from shale. Author(s): Crosby, L. M. Orem, W. H.
Chapter: 24 (Page no: 353) Minamata disease and methylmercury exposure. Author(s): Hachiya, N.
Chapter: 25 (Page no: 371) Lead poisoning. Author(s): Katner, A. L. Mielke, H. W.
Chapter: 26 (Page no: 384) Cadmium I. Exposure and human health effects: an overview. Author(s): Åkesson, A. Kippler, M.
Chapter: 27 (Page no: 394) Cadmium II. Cardiovascular effects of human exposure to cadmium: left ventricular structure and function. Author(s): Yang, W. Y. Staessen, J. A.
Chapter: 28 (Page no: 405) Particulates from combustion sources: formation, characteristics and toxic hazards. Author(s): Purser, D. A.
Chapter: 29 (Page no: 424) Assessment of the ecotoxicity of airborne particulate matter. Author(s): Kováts, N.
Chapter: 30 (Page no: 436) Toxicity of microplastics in the marine environment. Author(s): Santana, M. F. M. Turra, A.
Chapter: 32 (Page no: 475) Radon I. Lung cancer risks. Author(s): Melloni, B.
Chapter: 33 (Page no: 484) Radon II. Leukaemia or CNS cancer risks among children. Author(s): Kollerud, R. del R.
Chapter: 34 (Page no: 497) Fukushima nuclear accident: potential health effects inferred from butterfly and human cases. Author(s): Otaki, J. M.
Chapter: 35 (Page no: 517) Microbial remediation of contaminated soils. Author(s): Shahsavari, E. Mansur, A. A. Aburto-Medina, A. Haleyur, N. Jones, N. Ball, A. S.
Chapter: 36 (Page no: 531) Metallic iron for environmental remediation: prospects and limitations. Author(s): Noubactep, C.
Chapter: 37 (Page no: 545) Remediation of contaminated soil by biochar. Author(s): Sima, X. F. Jiang, H.
Chapter: 38 (Page no: 561) Environmental regulations in China. Author(s): He, G. Z.
Chapter: 39 (Page no: 577) 21st Century toxicology: methods for environmental toxicology and monitoring. Author(s): Lundqvist, J.
Chapter: 40 (Page no: 587) Unequivocal evidence associating environmental contaminants and pollutants with human morbidity and ecological degradation. Author(s): D'Mello, J. P. F.

Chapter details

  • Author Affiliation
  • Instituto de Biología Molecular y Celular (IBMC), and Instituto de Investigacion, Desarrollo e Innovacion en Biotecnologia Sanitaria de Elche (IDiBE), Universitas Miguel Hernández (UMH), 03202 Elche, Spain.
  • Year of Publication
  • 2020
  • ISBN
  • 9781786394675
  • Record Number
  • 20193493761