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CAB eBooks

Ebooks on agriculture and the applied life sciences from CAB International

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CABI Book Chapter Info
Cover for The developmental neurotoxicity of polychlorinated biphenyls: a continuing environmental health concern.

Polychlorinated biphenyls (PCBs) are synthetic chemicals widely used in diverse industrial applications and commercial products until their production was banned in the 1970s due to concerns regarding their environmental persistence and human health risks. Despite the ban, environmental levels of...

Author(s)
Sethi, S.; Lein, P. J.
ISBN
2020 CABI (H ISBN 9781786394675)
Type
Book chapter
CABI Book Info
Cover for Amino acids in human nutrition and health.

The chapters in this book are arranged within a thematic structure as indicated in the sections below. The first part pursues the theme of amino acid metabolism through the driving actions of the principal enzymes, emphasizing recent developments particularly with reference to localization,...

Author(s)
D'Mello, J. P. F.
ISBN
2012 CABI (H ISBN 9781845937980)
Type
Book
CABI Book Chapter Info
Cover for Aminotransferases.

The aminotransferases are PLP-dependent proteins which catalyse the transfer of an amino group from the donor amino acid to α-ketoglutarate, forming glutamate and the respective keto acids. Several key aminotransferase proteins have been identified as playing central roles in whole-body nitrogen...

Author(s)
Conway, M. E.
ISBN
2012 CABI (H ISBN 9781845937980)
Type
Book chapter
CABI Book Chapter Info
Cover for Histidine decarboxylase.

The mammalian histidine decarboxylase cDNA encodes for a protein with a molecular mass of 74 kDa that is converted into a 53-55 kDa form during post-translational proteolytic processing through the ubiquitin-proteasome system. The resulting enzyme, histidine decarboxylase, converts L-histidine to...

Author(s)
Dere, E.; Ambrée, O.; Zlomuzica, A.
ISBN
2012 CABI (H ISBN 9781845937980)
Type
Book chapter
CABI Book Chapter Info
Cover for Glutaminase.

A key role for phosphate-activated glutaminase has been proposed for the synthesis of neurotransmitter glutamate and γ-aminobutyric acid (GABA) in the brain. This synthesis must be exquisitely regulated because of its potential harmful effects giving rise to excitotoxic damage. It is noteworthy...

Author(s)
Matés, J. M.; Segura, J. A.; Alonso, F. J.; Márquez, J.
ISBN
2012 CABI (H ISBN 9781845937980)
Type
Book chapter
CABI Book Chapter Info
Cover for Tryptophan hydroxylase.

Tryptophan hydroxylases (TPH1 and TPH2) are the rate-limiting enzymes in the serotonin biosynthesis and have the most restricted tissue distribution of the aromatic amino acid hydroxylases. TPH1 is mainly found in the pineal gland and enterochromaffin cells of the gut, whereas TPH2 is the main TPH...

Author(s)
Winge, I.; McKinney, J.; Haavik, J.
ISBN
2012 CABI (H ISBN 9781845937980)
Type
Book chapter
CABI Book Chapter Info
Cover for Amino acid transport across each side of the blood-brain barrier.

Brain capillary endothelial cells form the blood-brain barrier (BBB). They are connected by extensive tight junctions, and are polarized into luminal (blood-facing) and abluminal (brain-facing) plasma membrane domains. The polar distribution of transport proteins mediates amino acid (AA)...

Author(s)
Hawkins, R. A.; Viña, J. R.; Peterson, D. R.; O'Kane, R.; Mokashi, A.; Simpson, I. A.
ISBN
2012 CABI (H ISBN 9781845937980)
Type
Book chapter
CABI Book Chapter Info
Cover for The umami taste of glutamate.

Umami, the savoury taste of L-glutamate, is one of the five basic taste qualities detected by humans. The umami taste receptor is a heteromeric complex of two class-C G protein-coupled receptors, T1R1 and T1R3. Breakthrough discoveries have been made in the molecular biology of the mammalian taste...

Author(s)
Li, X.
ISBN
2012 CABI (H ISBN 9781845937980)
Type
Book chapter
CABI Book Chapter Info
Cover for Efficacy of L-DOPA therapy in Parkinson's disease.

L-3,4-dihydroxyphenylalanine (L-DOPA) is a classical example of an amino acid that is an immediate precursor to dopamine and has been developed as an effective therapeutic agent for a neurodegenerative disease. Dopamine deficiency is known to be a core pathogenic event in Parkinson's disease (PD)....

Author(s)
Sahin, G.; Kirik, D.
ISBN
2012 CABI (H ISBN 9781845937980)
Type
Book chapter
CABI Book Chapter Info
Cover for Arginase.

Arginase is one of the several enzymes that metabolize the semi-essential amino acid, L-arginine. The other enzymes which metabolize L-arginine include: 1. Nitric oxide synthase (NO production). 2. Arginyl-tRNA synthetase (protein produ ction). 3. Arginine:glycine aminotransferase (creatine...

Author(s)
Caldwell, R. W.; Chandra, S.; Caldwell, R. B.
ISBN
2012 CABI (H ISBN 9781845937980)
Type
Book chapter

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